Personalized medicine and the clinical laboratory

Personalized medicine and the clinical laboratory

Personalized medicine is the use of biomarkers, most of them molecular markers, for detection of specific genetic traits to guide various approaches for preventing and treating different conditions. The identification of several genes related to heredity, oncology and infectious diseases lead to the detection of genetic polymorphisms that are involved not only in different clinical progression ...

pharmacogenetics, the promise of translating personalized medicine into clinical pediatrics

Personalized (laboratory) medicine: a bridge to the future.

Rapid advances in genomics and related technologies are promising a new era of personalized healthcare and disease prevention, not limited to new drugs, but also involving diagnostic and screening biomarkers. Although scientists have put forward the hypothesis that the time of personalized medicine has come (or will soon arrive), the chasm between new discoveries and the clinical use of new ins...

Clinical Practice Guidelines Formalization for Personalized Medicine

Clinical guidelines are important means to improve quality of health care while limiting cost and supporting the medical staff. They are written as free text with tables and figures. Transforming them into a formal, computer-processable representation is a difficult task requiring both computer scientist skills and medical knowledge. In this paper the authors describe a CDSS designed to assist ...

Active Clinical Trials for Personalized Medicine.

Individualized treatment rules (ITRs) tailor treatments according to individual patient characteristics. They can significantly improve patient care and are thus becoming increasingly popular. The data collected during randomized clinical trials are often used to estimate the optimal ITRs. However, these trials are generally expensive to run, and, moreover, they are not designed to efficiently ...